Phenotype Image Detail

Image

Caption

A and B: Aph1a^tm1.1Bdes/Aph1a^tm1.1Bdes embryos display a highly irregular contour of the neural tube. C-E: The strict radial organization of neural tube epithelia between lumen and head mesenchyme is partially lost in mutant mice. Within the neural tube, numerous cells are aligned obliquely (single arrowheads in D). Notice the multifocal emigration of neural cells into the surrounding mesenchyme (double arrowheads in D). Individual or grouped apoptotic cells are observed within the neural tube (arrows in E) and especially in the surrounding mesoderm (note massive surface blebbing indicated with arrowheads in G). Apoptosis is confirmed by immunostaining of cleaved caspase 3 (H and I) and also affects the trigeminal neural crest underlying the nasal and otic placodes and the head mesenchyme (tn in H and I) Scale bars: A and B, 200um; C-E, 30um; F and G, 20um; H and I, 100um. mb, midbrain; hb, hindbrain; ne, neuroepithelium; tn, trigeminal neural crest cells.

Copyright

This image is from Serneels L, Proc Natl Acad Sci U S A 2005 Feb 1;102(5):1719-24. Copyright 2005 National Academy of Sciences, U.S.A. J:96106

Associated Alleles

Symbol	Name
Aph1a^tm1.1Bdes	aph1 homolog A, gamma secretase subunit; targeted mutation 1.1, Bart De Strooper

Associated Genotypes

Allelic Composition	Genetic Background
Aph1a^tm1.1Bdes/Aph1a^tm1.1Bdes	involves: 129P2/OlaHsd * C57BL/6J