Phenotype Image Detail

Image

Caption

A and B: Plastic-embedded spinal cord sections from Hexb^tm1Rlp/Hexb^tm1Rlp (Hexb-/- GalNAcT+/+) (A) and Hexb^tm1Rlp/Hexb^tm1Rlp B4galnt1^tm1Rlp/B4galnt1^tm1Rlp (Hexb-/- GalNAcT-/-) (B) mice were stained with toluidine blue. Arrows indicate axonal degeneration. x270. C and D: Paraffin sections of cerebral cortex from single mutant (C) and double mutant (D) mice. Sections were stained with Luxol fast blue stain (LFB) and periodic acid-Schiff stain (PAS). Neuronal inclusions were stained blue (arrows) and perivascular macrophages were stained reddish-pink (arrowheads) x110. E and F: Electron micrographs of anterior horn neurons of spinal cord from single mutant (E) and double mutant (F) mice. x11,000. Note the differences in the contents of storage vacuoles (v).

Copyright

This image is from Liu Y, J Clin Invest 1999 Feb;103(4):497-505 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:53080

Associated Alleles

Symbol	Name
B4galnt1^tm1Rlp	beta-1,4-N-acetyl-galactosaminyl transferase 1; targeted mutation 1, Richard L Proia
Hexb^tm1Rlp	hexosaminidase B; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129S4/SvJae * C57BL/6
B4galnt1^tm1Rlp/B4galnt1^tm1Rlp Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6