Phenotype Image Detail

Image

Caption

Ear lobe biopsies from an Eng^tm1Mle/Eng⁺ mouse and normal littermate were left unstained (A and B) or were stained for beta-gal activity (C and D). A: A dilated vessel (arrow), engorged with blood, is seen in the affected heterozygous ear lobe, together with a necrotic area (arrowhead) from a telangiectasia ruptured previously. B: The corresponding area from a nonaffected control mouse shows much smaller vessels. C: A small telangiectasia (arrow), close to the edge of the affected ear, appears as a dilated vessel distinct from the adjacent netwrok of capillaries. D: Normal capillary network from a non affected ear. E: A cross-section of the resected ear segment from the affected heterozygous mouse was stained for beta-gal. An enlarged vessel filled with blood (arrow), corresponding to a telangiectasia, is seen. The endothelial cells of this vessel and of several normal small capillaries are stained; a layer of cartilage (ca) is seen across the section. Scale bar, A-D: 500um, E: 100um.

Copyright

This image is from Bourdeau A, J Clin Invest 1999 Nov;104(10):1343-51 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:58502

Associated Alleles

Symbol	Name
Eng^tm1Mle	endoglin; targeted mutation 1, Michelle Letarte

Associated Genotypes

Allelic Composition	Genetic Background
Eng^tm1Mle/Eng^+	129P2/OlaHsd-Eng^tm1Mle