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Phenotype Image Detail
Caption (a) Cervical, axillary, inguinal, and mesenteric lymph nodes were removed from a 2-month-old wild-type (WT) and Gbatm1Rlp/Gbatm1Rlp (L444P/L444P) mice. The lymph nodes of mutant mice (b) showed follicular hyperplasia and dilated parafollicular zones compared with the lymph nodes of control mice (c). Immunostaining for kappa light chain showed large numbers of positive cells in the lymph nodes of the mutant mice (d) compared with wild-type mice (e). Arrows point out a few of the positive cells. (f) Plasmacytosis in the cervical lymph node of a 9-month-old mutant mouse. Arrows point out a few of the abundant large plasma cells. Bars = 50um. (g) Left panel: IL-1beta mRNA expression in the cervical lymph nodes of mutant and wild type mice. Results are means +/- SEM for six mice. *P < 0.05. Right panel: Serum IgG levels in mutant and wild type mice. Results are means +/- SEM for five mice.
Copyright This image is from Mizukami H, J Clin Invest 2002 May;109(9):1215-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:76409
Symbol Name
Gbatm1Rlp glucosidase, beta, acid; targeted mutation 1, Richard L Proia
Allelic Composition Genetic Background
Gbatm1Rlp/Gbatm1Rlp involves: 129S4/SvJae * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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