Phenotype Image Detail

Image

Caption

Hepatic changes in Mst1^tm1Jab/Mst1^tm1Jab mice. Hematoxylin and eosin staining of histological sections of livers from wild type (A and C) and mutant mice (B and D) showing cytoplasmic vacuolizations in hepatocytes of mutant mice (arrows point to vacuoles in hepatocytes). In E, arrows show lipid accumulation in cytoplasmic vacuoles of hepatocytes from mutant mice, as demonstrated with Sudan black staining; arrowheads point to unstained nuclei. Transmission electron micrograph shows clear cytoplasmic droplets that are not membrane-bound in a background of normal-appearing organelles (* in F). A and B, x100; C and D, x200; E, x400; F, x3150.

Copyright

This image is from Bezerra JA, J Clin Invest 1998 Mar 1;101(5):1175-83 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:46185

Associated Alleles

Symbol	Name
Mst1^tm1Jab	macrophage stimulating 1 (hepatocyte growth factor-like); targeted mutation 1, Jorge A Bezerra

Associated Genotypes

Allelic Composition	Genetic Background
Mst1^tm1Jab/Mst1^tm1Jab	involves: 129P2/OlaHsd * Black Swiss