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Caption | A-D: Hematoxylin and eosin staining of testes from wild type (WT) (A and B) and Mlh1tm1Wed/Mlh1tm1Wed (Mlh1G67R/G67R) (C and D) males, showing normal progression of spermatogenesis in wild type and failure to progress beyond metaphase I in mutant adult testes. Aberrant spindle configurations are observed in testis sections from males (arrows). E and F: Metaphase spreads from wild type (E) and mutant (F) spermatocytes show abnormal metaphase configurations in the mutant mice. Almost all chromosomes are univalent, with only very few crossovers remaining (arrow) in mutant spermatocytes. Scale bar: A-D, 100um. | ||||
Copyright | This image is from Avdievich E, Proc Natl Acad Sci U S A 2008 Mar 18;105(11):4247-52. Copyright 2008 National Academy of Sciences, U.S.A. J:133352 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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