Phenotype Image Detail

Image

Caption

Proliferation, apoptosis, and expression of Sox family proteins in Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b^tm1Kml Tg(Col2a1-cre)1Bhr/? mice (Bmpr1a^CKO; Bmpr1b^-/-). A: Proliferating cell nuclear antigen (PCNA) labeling of E12.5 condensations showing essentially no proliferation in mutants. B: TUNEL labeling reveals an increase in apoptosis in mutant condensations. C-E: In situ hybridizations for Sox9 (C), L-Sox5 (D), and Sox6 (E) show that expression is significantly reduced in Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b^tm1Kml Tg(Col2a1-cre)1Bhr/? condensations.

Copyright

This image is from Yoon BS, Proc Natl Acad Sci U S A 2005 Apr 5;102(14):5062-7. Copyright 2005 National Academy of Sciences, U.S.A. J:97410

Associated Alleles

Symbol	Name
Bmpr1a^tm2.1Bhr	bone morphogenetic protein receptor, type 1A; targeted mutation 2.1, Richard R Behringer
Bmpr1b^tm1Kml	bone morphogenetic protein receptor, type 1B; targeted mutation 1, Karen M Lyons
Tg(Col2a1-cre)1Bhr	transgene insertion 1, Richard R Behringer

Associated Genotypes

Allelic Composition	Genetic Background
Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b^tm1Kml Tg(Col2a1-cre)1Bhr/?	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL