Phenotype Image Detail

Image

Caption

Shown are hematoxylin and eosin stained sections (A and C) and TUNEL assay (B and D). A and B: Wild type (WT) and Vdr^tm1Mbd/Vdr^tm1Mbd (KO) mice fed a regular diet (Left) or a rescue diet (Right) that normalized mineral ion homeostasis. C and D: Wild type mice fed a regular diet, Phex^Hyp/? (Hyp) mice fed a regular diet, and wild type mice fed a high-calcium/low-phosphate diet from 18 to 24 days of age. Brackets indicate the hypertrophic chondrocyte layer. Data are representative of experiments performed on sections from three or more mice for each condition. EV, Evans blue; T, TUNEL.

Copyright

This image is from Sabbagh Y, Proc Natl Acad Sci U S A 2005 Jul 5;102(27):9637-42. Copyright 2005 National Academy of Sciences, U.S.A. J:99866

Associated Alleles

Symbol	Name
Phex^Hyp	phosphate regulating endopeptidase homolog, X-linked; hypophosphatemia
Vdr^tm1Mbd	vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1, Marie B Demay

Associated Genotypes

Allelic Composition	Genetic Background
Vdr^tm1Mbd/Vdr^tm1Mbd	involves: 129S4/SvJae * C57BL/6J
Phex^Hyp/?	involves: C57BL/6J