Phenotype Image Detail

Image

Caption

A and B: Hematoxylin and eosin staining of a portal triad of control (Xylt2⁺/⁺) liver (A) and Xylt2^tm1Meh/Xylt2^tm1Meh (Xylt2^-/^-) (B). Arrowhead indicates biliary tract. Arrows show hyperplastic biliary tract. Scale bar: 100um. E: Sirius red staining for collagen. (Upper) Bright field and epipolarized light microscopy. (Lower) Same section examined with epipolarized light only. Mutant mouse portal triad shows increased periportal fibrous connective tissue as red-amber structures (Upper) and green shimmering structures (Lower). Scale bars: 100um. F: MRI analyses of liver cysts in the same female mutant mouse at different ages. Arrowheads indicate the spinal cord. C1 indicates a liver cyst that was present at 4 months of age and virtually absent at 7 months of age. C2 indicates a new cluster of cysts at 7 months of age that is still present and enlarged at 10 months of age. C(1) indicates either the healing and refilling of C1 or a new cyst in the 10 month old mutant liver.

Copyright

This image is from Condac E, Proc Natl Acad Sci U S A 2007 May 29;104(22):9416-21. Copyright 2007 National Academy of Sciences, U.S.A. J:122291

Associated Alleles

Symbol	Name
Xylt2^tm1Meh	xylosyltransferase II; targeted mutation 1, Myron E Hinsdale

Associated Genotypes

Allelic Composition	Genetic Background
Xylt2^tm1Meh/Xylt2^tm1Meh	involves: 129P2/OlaHsd