Phenotype Image Detail

Image

Caption

Primary squamous cell carcinoma metastasis in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice. A: Underside of skin from tumor-bearing mouse shows newly formed blood vessels surrounding tumor site (arrow) and leading to inguinal lymph node (arrowhead). B: Enlarged inguinal lymph node (left) containing metastatic squamous cell carcinoma (SCC) and blood vessel formation (arrow) compared to normal lymph node (right). C: Hematoxylin and eosin stain of carcinoma section with prominent blood vessel (bv). Carcinoma cells (ca) have penetrated blood vessel wall (arrow). D: Hematoxylin and eosin stain of lymph node bearing infiltrating SCC cells (arrow) among normal lymphocytes (arrowhead). E: Hematoxylin and eosin stain of lymph node bearing metastatic differentiated SCC. F: Immunostain with pan-keratin antibody of papilloma. G: Immunostain with pan-keratin antibody of lymph node with metastatic SCC. H and I: Hematoxylin and eosin stain of normal lung (arrowhead) with large metastatic SCC deposit (arrow). J: Hematoxylin and eosin stain of lung metastasis with secondary site of infiltration (arrow). Magnification: D-G and J, 20x; Inserts in E-G, 40x.

Copyright

This image is from Kelly-Spratt KS, PLoS Biol 2004 Sep;2(8):E242, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:93298

Associated Alleles

Symbol	Name
Cdkn2a^tm1Cjs	cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr

Associated Genotypes

Allelic Composition	Genetic Background
Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs	involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd