Phenotype Image Detail

Image

Caption

A-C: Wild type and Mrtfb^tm1Eno/Mrtfb^tm1Eno embryos at E10.5 (A) and E11.5 (B and C). Hematoxylin and eosin stained sections show hypoplastic sixth arch arteries in mutant embryos. Abnormal communication between the fourth and sixth arteries at E10.5 is indicated (*). Histological sections stained for SM alpha-actin show smooth muscle differentiation within the wall of branchial arch arteries and dorsal aortae in the wild type embryo. In contrast, SM alpha-actin expression is not detected in the branchial arch arteries of the mutant embryo, but expression is seen in the dorsal aorta and heart. Branchial arch arteries are numbered as 3, 4, and 6. da, dorsal aorta. D: Schematic of branchial arch arteries. The plane of section in the embryos shown in A-C is indicated by a dashed line. as, aortic sac; lda, left dorsal aorta; rda, right dorsal aorta. E: Transverse section through the heart shows incomplete ventricular septation (arrowhead) and thin myocardial wall in the mutant embryo at E13.5. lv, left ventricle; rv, right ventricle.

Copyright

This image is from Oh J, Proc Natl Acad Sci U S A 2005 Oct 18;102(42):15122-7. Copyright 2005 National Academy of Sciences, U.S.A. J:102475

Associated Alleles

Symbol	Name
Mrtfb^tm1Eno	myocardin related transcription factor B; targeted mutation 1, Eric N Olson

Associated Genotypes

Allelic Composition	Genetic Background
Mrtfb^tm1Eno/Mrtfb^tm1Eno	involves: 129S/SvEv * C57BL/6