Phenotype Image Detail

Image

Caption

Lower magnification (x200 in a,c,e,g and i-p) and higher magnification (x400 in b,d,f & h) images are shown. Arrowheads (i-l) refer to morphologically degenerating germ cells, and arrows point to TUNEL positive cells (brown). Morphology and TUNEL assay of adult (8 week old) Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} (a & b), Pafah1b3^tm1Cla/Pafah1b3^tm1Cla Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} (c & d) Pafah1b3^tm1Cla/Pafah1b3^tm1Cla Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} Pafah1b1^tm1Awb/Pafah1b1⁺ (e & f) and Pafah1b1^tm1Awb/Pafah1b1⁺ (g & h) testes are presented. Morphology and TUNEL assays of wild type (i & m), Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} (j & n), double mutant (k & o) and triple mutant (l & p) testes at P20 are shown.

Copyright

This image is from Yan W, Proc Natl Acad Sci U S A 2003 Jun 10;100(12):7189-94. Copyright 2003 National Academy of Sciences, U.S.A. J:83818

Associated Alleles

Symbol	Name
Pafah1b1^tm1Awb	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; targeted mutation 1, Anthony Wynshaw-Boris
Pafah1b2^Gt(Betageo)1Cla	platelet-activating factor acetylhydrolase, isoform 1b, subunit 2; gene trap 1, Gary D Clark
Pafah1b3^tm1Cla	platelet-activating factor acetylhydrolase, isoform 1b, subunit 3; targeted mutation 1, Gary D Clark

Associated Genotypes

Allelic Composition	Genetic Background
Pafah1b2^Gt(Betageo)1Cla/Pafah1b2^Gt(Betageo)1Cla	involves: 129S6/SvEvTac
Pafah1b2^Gt(Betageo)1Cla/Pafah1b2^Gt(Betageo)1Cla Pafah1b3^tm1Cla/Pafah1b3^tm1Cla	involves: 129S6/SvEvTac
Pafah1b1^tm1Awb/Pafah1b1^+ Pafah1b2^Gt(Betageo)1Cla/Pafah1b2^Gt(Betageo)1Cla Pafah1b3^tm1Cla/Pafah1b3^tm1Cla	involves: 129S6/SvEvTac