Phenotype Image Detail

Image

Caption

A microglial cell with large inclusions, juxtaposed to a neuron in the cortex of a 6 month old Naglu^tm1Efn/Naglu^tm1Efn mouse. M and N identify the nucleus of the microglia and of the neuron, respectively. Note the large, nearly empty inclusions in the microglia (**) and the much smaller denser inclusions in the neuron (*). Arrowheads trace the membrane of the neuron. Scale bar, 5um.

Copyright

This image is from Ohmi K, Proc Natl Acad Sci U S A 2003 Feb 18;100(4):1902-7. Copyright 2003 National Academy of Sciences, U.S.A. J:81974

Associated Alleles

Symbol	Name
Naglu^tm1Efn	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB); targeted mutation 1, Elizabeth F Neufeld

Associated Genotypes

Allelic Composition	Genetic Background
Naglu^tm1Efn/Naglu^tm1Efn	involves: 129S/SvEv * C57BL/6