Phenotype Image Detail

Image

Caption

Skeletal preparations from 6 week old Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor⁺ Tg(Col2a1-cre)1Bhr/0 and control mice. A: Intact skeletons, control (left) and mutant (right). B: Dorsal view of skulls, control (left), mutant (right). C: Individual dorsal skull bones, control (left), mutant (right). D: Isolated forelimbs, mutant (top), control (bottom). E: Isolated hindlimbs, mutant (top), control (bottom) . F: Third lumbar vertebrae, showing lateral ossifications (arrow) in the control (left) that are hypoplastic in the mutant (right). G: Isolated pelvic bones from 6 week old mice, control (left) and mutant (right). H: Higher magnification of boxed region shown in panel G, showing pubic and ischial bone fusion of the control. I: Higher magnification of boxed regions shown in panel G, showing lack of fusion between the pubic and ischial bones of the mutant. fr, frontal bone; nas, nasal bone; par, parietal bone; oc, occipital bone.

Copyright

This image is from Lee HH, PLoS ONE 2007;2(5):e450, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:129327

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1(Wnt4)Bhr	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Richard R Behringer
Tg(Col2a1-cre)1Bhr	transgene insertion 1, Richard R Behringer

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor^+ Tg(Col2a1-cre)1Bhr/0	involves: 129S7/SvEvBrd * C57BL/6 * SJL