Phenotype Image Detail

Image

Caption

A-C: Transverse and oblique (through the plane of the ascending aorta) sections, and 3D reconstruction (left ventral oblique view) of a heart of a wild type embryo at 15.5dpc. The left and right ventricles (lv, rv) are separated by the interventricular septum (ivs). The left and right atria (la, ra), and the trachea (tr) are also indicated. The ascending aorta (a-ao) arises from the left ventricular outflow tract (lvot), via the aortic valve (ao-v), and continues on as the aortic arch (ao-a), which joins the descending aorta (d-ao). The pulmonary artery (pa) arises from the right ventricular outflow tract (rvot), and continues as the arterial duct (ad), which joins the descending aorta. D-F: Corresponding images of a Jmjd6^tm1Gbf/Jmjd6^tm1Gbf embryo, showing a smaller heart with a ventricular septal defect (VSD). The aorta arises from the right ventricle. The pulmonary artery is small and its connection to the descending aorta (arterial duct) could not be identified. G-I: Corresponding images of another homozygous mutant embryo, showing a VSD. The aorta overrides the VSD resulting in a double outlet right ventricle. J & K: Coronal sections of wild type and mutant embryos, showing the two lobes of the thymus (th). The aterial duct of the pulmonary artery in the mutant embryo is narrowed.

Copyright

This image is from Schneider JE, BMC Dev Biol 2004 Dec 22;4(1):16, an open-access article, licensee BioMed Central Ltd. J:102098

Associated Alleles

Symbol	Name
Jmjd6^tm1Gbf	jumonji domain containing 6; targeted mutation 1, Andreas Lengeling

Associated Genotypes

Allelic Composition	Genetic Background
Jmjd6^tm1Gbf/Jmjd6^tm1Gbf	C57BL/6-Ptdsr^tm1Gbf