Phenotype Image Detail

Image

Caption

Transmission electron micrographs of the outer plexiform layer in Crx^tm1Clc/Crx^tm1Clc retinas. A: In wild type mouse retina at P21, newly formed rod spherules were abundant (arrow demonstrates one example). The spherules were club shaped and contained a single invaginating synapse with one ribbon complex. Cone terminals form large, flat pedicles that contain many invaginating synapses with separate ribbon structures. These terminals were more scarce, but apparent in wild type retinas at P21 (one example in box). B: In the outer plexiform layer (OPL) of mutant mouse retinas, photoreceptor terminals appeared highly disorganized at P21 (arrows). Well formed pedicles and spherules were not evident. Putative terminals containing ribbon like structures were apparent, suggesting at least limited generation of synapse components. Many terminals appeared to contain multiple ribbon like structures, instead of a single ribbon. For example terminal 1 and 2 contained two ribbons each, whereas terminal 3 appeared to contain only one. Abbreviations: opl, outer plexiform layer. Scale bar: 2um

Copyright

This image is from Morrow EM, BMC Neurosci 2005 Jan 27;6(1):5, an open-access article, licensee BioMed Central Ltd. J:95886

Associated Alleles

Symbol	Name
Crx^tm1Clc	cone-rod homeobox; targeted mutation 1, Constance L Cepko

Associated Genotypes

Allelic Composition	Genetic Background
Crx^tm1Clc/Crx^tm1Clc	involves: 129S6/SvEvTac