Phenotype Image Detail

Image

Caption

Scanning electron microscopy of developing photoreceptors viewed from the scleral side with pigmented epithelium removed at P7, P14 and P21 for wild type (A,C & E) and Crx^tm1Clc/Crx^tm1Clc (B, D & F) littermates. In wild type retina, numerous connecting cilia (A, cc) were evident at P7 with rudimentary outer segments. After P7, in wild type outer segments elongation occurs. Initially, outer segments have a paddle-like structure (C, os) which is later shed (E, os). In mutant mouse photoreceptors, few connecting cilia were observed at P7 (B,cc). After P7, connecting cilia were more numerous and occasionally a malformed outer segment was noted extending from a connecting cilium (D & F, cc*). There were rarely observed in wild type mice and only at P14 (C, cc*). At P21, abnormally long connecting cilia were noted in mutant mice (F, cc). Scale bar: 10um

Copyright

This image is from Morrow EM, BMC Neurosci 2005 Jan 27;6(1):5, an open-access article, licensee BioMed Central Ltd. J:95886

Associated Alleles

Symbol	Name
Crx^tm1Clc	cone-rod homeobox; targeted mutation 1, Constance L Cepko

Associated Genotypes

Allelic Composition	Genetic Background
Crx^tm1Clc/Crx^tm1Clc	involves: 129S6/SvEvTac