Phenotype Image Detail

Image

Caption

Analysis of LS sections of E10.25 wild type and Mapk7^tm1Jsca/Mapk7^tm1Jsca embryos at low (A) and high (B) magnification shows that there was less contact between the neuroepithelium and cephalic mesenchyme (black arows) in mutant embryos, and that the cephalic mesenchyme was less dense with larger spaces between the cells in mutant embryos (green arrows) (C). The cephalic mesenchyme was almost completely absent in mutant embryos and the neuroepithelium was thinner. In mutant embryos at E9.75 the TS sections (D & E) through the cephalic mesenchyme again show less mesenchymal tissue in the mutant embryos, however major blood vessels (arrows) were seen in both wild type and mutant embryos. In contrast to wild type embryos, where little bleeding was seen in the cephalic mesenchyme, in mutant embryos bleeding into the cephalic mesenchyme was seen, especially where the mesenchymal tissue was absent (arrows in mutant embryos in D & E).

Copyright

This image is from Yan L, BMC Dev Biol 2003 Dec 16;3():11, an open-access article, licensee BioMed Central Ltd. J:107620

Associated Alleles

Symbol	Name
Mapk7^tm1Jsca	mitogen-activated protein kinase 7; targeted mutation 1, J Simon C Arthur

Associated Genotypes

Allelic Composition	Genetic Background
Mapk7^tm1Jsca/Mapk7^tm1Jsca	either: (involves: BALB/c) or (involves: C57BL/6)