Phenotype Image Detail

Image

Caption

A: Wild type acinar cells have normal cellular morphology and contained abundant numbers of zymogen granules (ZGs) (seen as black circular vesicles containing electron dense material), and electron-dense material from ZGs is present in the ductal lumen (white arrow). B-D: Serpini2^pq/Serpini2^pq mice have fewer and smaller ZGs and no dense material in the ductal lumen (L) when compared to wild type mice. A significant number of acinar cells are undergoing apoptosis, as indicated by the presence of cellular phagocytosis (C & D), rough endoplasmic reticulum whirling bodies ( B C) (black arrows), and nuclear condensation and fragmentation (D) (asterisk). E & F: TUNEL staining of 3 week old pancreas tissue from wild type (E) and homozygous (F) mice indicates an increase in TUNEL-positive, red-fushcin-staining cells in homozygous mice compared to wild type mice. Abbreviations: L, lumen; N, nucleus; RER, rough endoplasmic reticulum. Scale bars: A-D, 5um; E & F, 50um

Copyright

This image is from Loftus SK, PLoS Genet 2005 Sep;1(3):e38, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:115744

Associated Alleles

Symbol	Name
Serpini2^pq	serine (or cysteine) peptidase inhibitor, clade I, member 2; pequeno

Associated Genotypes

Allelic Composition	Genetic Background
Serpini2^pq/Serpini2^pq	involves: C57BL/6J