Phenotype Image Detail

Image

Caption

A-D: Wild type and Nfia^tm1Rmg/Nfia⁺ Tg(Hoxb7-EGFP)33Cos newborns with megaureter (with extent of dilation indicated by two-headed arrow) (A, C) and partial ureteral duplication (arrow) in the Nfia^tm1Rmg/Nfia⁺ Tg(Hoxb7-EGFP)33Cos (C). Higher power views of boxed areas in (A) and (C), showing distortion of the heterozygous mutant ureter at the UNJ (B & D); note that the vas deferens in the heterozygous male (C) is also GFP-positive. E & F: Abnormalities in the homozygous mutant newborns include proximal flexion of the ureter (E) and dysplastic kidney (F). Abbreviations: k, kidney; t, testis; ur, ureter. UNJ, ureterovesical junction; v, vas deferens

Copyright

This image is from Lu W, PLoS Genet 2007 May 25;3(5):e80, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:122749

Associated Alleles

Symbol	Name
Nfia^tm1Rmg	nuclear factor I/A; targeted mutation 1, Richard M Gronostajski
Tg(Hoxb7-EGFP)33Cos	transgene insertion 33, Franklin Costantini

Associated Genotypes

Allelic Composition	Genetic Background
Nfia^tm1Rmg/Nfia^tm1Rmg Tg(Hoxb7-EGFP)33Cos/?	involves: 129P2/OlaHsd * C57BL/6 * CBA
Nfia^tm1Rmg/Nfia^+ Tg(Hoxb7-EGFP)33Cos/?	involves: 129P2/OlaHsd * C57BL/6 * CBA