Phenotype Image Detail

Image

Caption

(A & B) Control E14.5 forelimb (A) compared to an E14.5 Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.2Bhr Tg(Gdf5-cre,-ALPP)1Kng/0 mouse forelimb (B) showing webbing between digits 1 and 2 (arrowheads) and extra tissue at the posterior of digit 5 (arrows). (G & H) By 15.5, interdigital tissue has regressed in controls (G, arrowhead). In contrast, tissue remains in mutants at this location.

Copyright

This image is from Rountree RB, PLoS Biol 2004 Nov;2(11):e355, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:97780

Associated Alleles

Symbol	Name
Bmpr1a^tm2.1Bhr	bone morphogenetic protein receptor, type 1A; targeted mutation 2.1, Richard R Behringer
Bmpr1a^tm2.2Bhr	bone morphogenetic protein receptor, type 1A; targeted mutation 2.2, Richard R Behringer
Tg(Gdf5-cre,-ALPP)1Kng	transgene insertion 1, David M Kingsley

Associated Genotypes

Allelic Composition	Genetic Background
Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.2Bhr Tg(Gdf5-cre,-ALPP)1Kng/0	involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng