Phenotype Image Detail

Image

Caption

A-C: Hematoxylin and eosin stained histology depicts duplication and dilatation of ureter at the ureteropelvic junction (UPJ) in Nfia^tm1Rmg/Nfia⁺ (B) and Nfia^tm1Rmg/Nfia^tm1Rmg newborn mice (C) compared with the wild type mouse (A). D-F: Hematoxylin and eosin staining shows dilatation of the ureterovesical junction (UVJ) in some Nfia^tm1Rmg/Nfia⁺ mutant mice (* in E), the majority of Nfia^tm1Rmg/Nfia⁺ and Nfia^tm1Rmg/Nfia^tm1Rmg mice show a normal UVJ (F) compared with the wild type mouse (D). Magnification: 60X. Abbreviations: a; abdominal aorta; bl: bladder; pe: pelvis; r: rectum; ur: ureter.

Copyright

This image is from Lu W, PLoS Genet 2007 May 25;3(5):e80, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:122749

Associated Alleles

Symbol	Name
Nfia^tm1Rmg	nuclear factor I/A; targeted mutation 1, Richard M Gronostajski

Associated Genotypes

Allelic Composition	Genetic Background
Nfia^tm1Rmg/Nfia^tm1Rmg	involves: 129P2/OlaHsd * C57BL/6
Nfia^tm1Rmg/Nfia^+	involves: 129P2/OlaHsd * C57BL/6