Phenotype Image Detail

Image

Caption

A: Wild type (left) and Tfap2a^Mhdador/Tfap2a^Mhdador (right) embryos at 18.5. The homozygous mutant embryos have smaller eyes (arrow) and abnormal facial structure in the form of a shorter and/or narrower snout. B-E: H & E staining of sections of E18.5 eyes from wild type (B), Tfap2a^Mhdador/Tcfap2a⁺ (C) and homozygous embryos (D & E). Homozygous mice show variability in ocular phenotype with adhesion of a smaller lens to the cornea (col) (D) or absencce of lens (E). The neuroretina (nr) is folded in some embryos (E) and occasionally anterior eye structures, such as the iris, and ciliary body, fail to form and instead devekop into a neuroretina (nr, E).

Copyright

This image is from Ahituv N, Mamm Genome 2004 Jun;15(6):424-32 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:90701

Associated Alleles

Symbol	Name
Tfap2a^Mhdador	transcription factor AP-2, alpha; Martin Hrabe de Angelis doarad

Associated Genotypes

Allelic Composition	Genetic Background
Tfap2a^Mhdador/Tfap2a^Mhdador	involves: C3HeB/FeJ