Phenotype Image Detail

Image

Caption

Cross sections of the cochlea from the temporal bones of (A) wild type and (B) Ednrb^WS4/Ednrb^WS4 mice. Note the thin stria vascularis (SV) and shift of Reissner membrane (RM) toward the stria vascularis in the homozygous mutant mouse. Severity of endolymphatic collapse was variable in each cochlea; in this particular cochlea, endolymphatic space was partially collapsed. While outer hair cells (OHC) are visible in the organ of Corti on basement membrane (BM) in the wild type mouse, the organ of Corti is severely degenerated in the homozygous mouse and hair cells are not discernible. Scale bars: 100um

Copyright

This image is from Matsushima Y, Mamm Genome 2002 Jan;13(1):30-5 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:76584

Associated Alleles

Symbol	Name
Ednrb^WS4	endothelin receptor type B; Waardenburg syndrome 4

Associated Genotypes

Allelic Composition	Genetic Background
Ednrb^WS4/Ednrb^WS4	involves: BALB/c * MSM