Phenotype Image Detail

Image

Caption

A & B: LFB stain of P11.5 and P15.5 Ctsb^tm1Jde/Ctsb^tm1Jde Ctsl^tm1Cptr/Ctsl^tm1Cptr cortical neurons. At P11.5 (A), only a few inclusions are observed in some neuronal perikarya (arrow). The arrowhead points to a normal neuron. At P15.5 (B), the perikarya are expanded and filled with LFB-positive inclusions. C-E: Electron micrographs of inclusions in P12.5 (C & D) and P24.5 (E) double mutant cortical neurons. D: Higher magnification of the inclusion indicated by an arrow in C. F: Sagittal section of the P11.5 double mutant brain shown in A revealing a dense accumulation of eosinophilic globules in cerebral white matter (H&E stain). G & H: Magnification of the area surrounding the asterisk shown in F stained with H & E and LFB, respectively. Normal white matter is seen in the upper right corner. I: Electron micrograph of membranous inclusions in a swollen axon in the corpus callosum of P12.5 double mutant mouse. Scale bars: A,B,G & H, 15um; C, 2um; D, 100nm; E, 1.6umm; F, 0.15mm; I, 500nm.

Copyright

This image is from Felbor U, Proc Natl Acad Sci U S A 2002 Jun 11;99(12):7883-8. Copyright 2002 National Academy of Sciences, U.S.A. J:77103

Associated Alleles

Symbol	Name
Ctsb^tm1Jde	cathepsin B; targeted mutation 1, Jan Deussing
Ctsl^tm1Cptr	cathepsin L; targeted mutation 1, Christoph Peters

Associated Genotypes

Allelic Composition	Genetic Background
Ctsb^tm1Jde/Ctsb^tm1Jde Ctsl^tm1Cptr/Ctsl^tm1Cptr	involves: 129P2/OlaHsd * C57BL/6J