Phenotype Image Detail

Image

Caption

A-C: Cryosections of the cerebral cortex of control (A) and Ctsb^tm1Jde/Ctsb^tm1Jde Ctsl^tm1Cptr/Ctsl^tm1Cptr mice at P24.5 (B & C) showing small TUNEL-positive globules in the center of a shrunken double mutant mouse neuron in B and division into apoptotic cell fragments in C. D & E: At P24.5 the granule layer of the cerebellar central lobe of control (D) and double mutant (E) shows TUNEL-positive material around the periphery of the double mutant nuclei, suggesting chromatin margination. F-I: GFAP-immunostaining of 6um coronal paraffin sections reveals abundant star-shaped hypertrophic astrocytes in the 50 day old double mutant cerebral cortex (G) not present in the control cortex (F). Control (H) and double mutant (I) 50 day old cerebellum shows the picture of an isomorphic gliosis in the latter. The process of the Bergmann glia are in parallel orientation. Note the tiny healthy area in I with a residual Purkinje cell (arrow). Scale bars: A-E, 7um; F-I, 0.1mm.

Copyright

This image is from Felbor U, Proc Natl Acad Sci U S A 2002 Jun 11;99(12):7883-8. Copyright 2002 National Academy of Sciences, U.S.A. J:77103

Associated Alleles

Symbol	Name
Ctsb^tm1Jde	cathepsin B; targeted mutation 1, Jan Deussing
Ctsl^tm1Cptr	cathepsin L; targeted mutation 1, Christoph Peters

Associated Genotypes

Allelic Composition	Genetic Background
Ctsb^tm1Jde/Ctsb^tm1Jde Ctsl^tm1Cptr/Ctsl^tm1Cptr	involves: 129P2/OlaHsd * C57BL/6J