Phenotype Image Detail

Image

Caption

A-I: Whole mount embryos of wild type (A,D, & G) and Frs2^tm1Schl/Frs2^tm1Schl mice where eye development is either mildly (B, E & H) or severely (C,F & I) affected. A-C: E14.5. D-I: E15.5. At higher magnification (G-I), microphthalmia (H) or anophthalmia (I) is clearly apparent. J: E9.5 wild type (left) and homozygous mutant embryos showing formation of the optic vesicle. K-L: Frs2^tm2Schl/Frs2^tm2Schl mice have no microphthalmia or anophthalmia apparent at E14.5 (K) and are smaller than wild type at the day of birth (L). In situ hybridization using Frs2alpha antisense (M) and control sense (N) probes on wild type E9,5 embryos. O: Cryosection of the eye region of the embryo shown in M. P: In situ hybridization on E9.5 embryo using Frsbeta antisense probe. Abbreviations: ov: optic vesicle; br: branchial arch; op: otic pit; lb: limb bud; lp: lens placode

Copyright

This image is from Gotoh N, Proc Natl Acad Sci U S A 2004 Dec 7;101(49):17144-9. Copyright 2004 National Academy of Sciences, U.S.A. J:94724

Associated Alleles

Symbol	Name
Frs2^tm1Schl	fibroblast growth factor receptor substrate 2; targeted mutation 1, Joseph Schlessinger
Frs2^tm2Schl	fibroblast growth factor receptor substrate 2; targeted mutation 2, Joseph Schlessinger

Associated Genotypes

Allelic Composition	Genetic Background
Frs2^tm2Schl/Frs2^tm2Schl	involves: 129S2/SvPas
Frs2^tm1Schl/Frs2^tm1Schl	involves: 129S2/SvPas * Swiss Webster