Phenotype Image Detail

Image

Caption

Wild type (A) and Zfpm1^tm1Sho/Zfpm1^tm1Sho Tg(Gata1-Zfpm1)1Sho (B) embryos at E14.5 show edema and hemorrhage in the mutant. Transverse sections of wild type (C) and mutant (D) hearts at E14.5 show aorta and pulmonary trunk arising from the right ventricle in the mutant. Transverse sections of wild type (E) and mutant (F) hearts at E14.5 show a common AV valve with ventricular septal defect in the mutant. G: Section of the ventricular wall of a mutant embryo at E14.5. The arrow identifies a coronary vessel. Magnifications: A-F: x100; G: x400

Copyright

This image is from Katz SG, Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14030-5. Copyright 2003 National Academy of Sciences, U.S.A. J:99745

Associated Alleles

Symbol	Name
Tg(Gata1-Zfpm1)1Sho	transgene insertion 1, Stuart Orkin
Zfpm1^tm1Sho	zinc finger protein, multitype 1; targeted mutation 1, Stuart Orkin

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Gata1-Zfpm1)1Sho/0 Zfpm1^tm1Sho/Zfpm1^tm1Sho	involves: 129S1/Sv * C57BL/6N * CD-1