Phenotype Image Detail

Image

Caption

A: Photographs of wild type, Gba1^tm1Rlp/Gba1^tm1Rlp (center) and Gba1^tm2Rlp/Gba1^tm2Rlp (right) mice within 12 hours after birth. The arrow denotes the presence of milk in the stomach. Note the small size and wrinkled skin of the Gba1^tm2Rlp/Gba1^tm2Rlp mouse. The skin of the Gba1^tm1Rlp/Gba1^tm1Rlp mouse is less severely wrinkled. The bracket indicates the sites where skin samples were taken for the photomicrographs in B. B: Section of epidermis. Stratum corneum (SC) of Gba1^tm1Rlp/Gba1^tm1Rlp and Gba1^tm2Rlp/Gba1^tm2Rlp mice are compacted and less eosinophillic compared with the loosely packed eosinophillic SC in the wild type mouse. No significant differences are noted in the three other layers of the epidermis (EP) (Stratum basale, stratum spinosum and stratum granulosum) or the dermis (D). Magnification x150

Copyright

This image is from Liu Y, Proc Natl Acad Sci U S A 1998 Mar 3;95(5):2503-8. Copyright 1998 National Academy of Sciences, U.S.A. J:46243

Associated Alleles

Symbol	Name
Gba1^tm1Rlp	glucosylceramidase beta 1; targeted mutation 1, Richard L Proia
Gba1^tm2Rlp	glucosylceramidase beta 1; targeted mutation 2, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
Gba1^tm1Rlp/Gba1^tm1Rlp	involves: 129S4/SvJae
Gba1^tm2Rlp/Gba1^tm2Rlp	involves: 129S4/SvJae