Phenotype Image Detail

Image

Caption

Histological sections of male (A-D) and female (E-H) fetal gonads are shown, comparing the gonads of wild type fetuses (A,C,E & G) with the abnormal gonads of Fancl^gcd/Fancl^gcd mouse fetuses (B,D,F & H). Gonads were stained with epoxy tissue stain (C,D,G & H) or for alkaline phosphatase activity (A,B,E & F). Many testicular cords of the 13.5 dpc homozygous mouse testis (T) were deficient in alkaline phosphatase-positive cells (germ cells) (B, arrowheads point to deficient testicular cords). The deficiency of germ cells was confirmed by conventional staining (D) where many primordial tubules contained supporting cells (S) but lacked germ cells (G). The analogous situation existed in fetal ovaries (O): homozygous mouse ovaries lacked germ cells (G), identified both by alkaline phosphatase activity and by conventional staining, but had a normal complement of supporting cells (S). Abbreviation: M: mesonephros

Copyright

This image is from Pellas TC, Proc Natl Acad Sci U S A 1991 Oct 1;88(19):8787-91. Copyright 1991 National Academy of Sciences, U.S.A. J:21254

Associated Alleles

Symbol	Name
Fancl^gcd	Fanconi anemia, complementation group L; germ cell deficient

Associated Genotypes

Allelic Composition	Genetic Background
Fancl^gcd/Fancl^gcd	involves: C57BL/6J * CBA/J