Phenotype Image Detail

Image

Caption

Degenerating neuron identifiable by synapses on its surface (curved arrow) from an Atm^tm1Bal/Atm^tm1Bal mouse. The synapses on the perikaryon, the clear, granular cytoplasm, the prominent, elongated Golgi apparatus, the lobulated nucleus with relatively homogeneous chromatin, and the prominent nucleolus are among the features that this cell shares with Golgi neurons in the normal cerebellum. However, this neuron presents multiple, often confluent vacuolations within the cytoplasm, indicating that it is undergoing a degenerative process. GCN: granule cell nucleus

Copyright

This image is from Kuljis RO, Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12688-93. Copyright 1997 National Academy of Sciences, U.S.A. J:44190

Associated Alleles

Symbol	Name
Atm^tm1Bal	ataxia telangiectasia mutated; targeted mutation 1, David Baltimore

Associated Genotypes

Allelic Composition	Genetic Background
Atm^tm1Bal/Atm^tm1Bal	involves: 129S4/SvJae