Phenotype Image Detail

Image

Caption

A-E: Limb defects of a Frem2^my-F11/Frem2^my-F11 mice. Shown are a fluid-filled blister on an E14.5 hind limb(A); a blood-filled blister encompassing distal structures of an E14.5 hind limb (B); a hemorrhage associated with malformation and dorsal flexure of the newborn hind limb (C); a malformed adult limb, showing reversal of flexure and soft tissue syndactyly (D); and a severely malformed adult limb (E). G: Section of an E15.5 mutant mouse heart, showing failure of atria septation (arrow) and a defect in ventricular valves (arrowhaed). Note that both ventricles drain into a single large chamber. H: Newborn mutant mouse lungs, showing failure of proper lung septation. The arrows point to lobe fusion. I: Section of newborn mutant mouse lung, showing normal morphology. The arrows denote regions where the lung lobes have fused, and the arrowhead denotes a region with a limited adhesion between the two lobes.

Copyright

This image is from Timmer JR, Proc Natl Acad Sci U S A 2005 Aug 16;102(33):11746-50. Copyright 2005 National Academy of Sciences, U.S.A. J:101189

Associated Alleles

Symbol	Name
Frem2^my-F11	Fras1 related extracellular matrix protein 2; my-F11

Associated Genotypes

Allelic Composition	Genetic Background
Frem2^my-F11/Frem2^my-F11	either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)