Phenotype Image Detail

Image

Caption

A: E10.5 embryos. The Snx13^tm1.1Frq/Snx13^tm1.1Frq embryo (left) is considerably smaller than its littermate (right) and has a neural tube closure defect. B: Whole mount staining for CD31 (PECAM-1) showing normal vascularization in the head of an E10.5 wild type embryo. C: Similar CD31 staining of homozygous mutant littermate with defect in cranial neural tube closure. Vascularization is particularly defective in the everted open neural tube. D & E: Placentas of wild type (D) and homozygous mutant (E) embryos. The placenta of the homozygous mutant embryo appears smaller (E Insert) and more hypoplastic than that of the wild type littermate. M, maternal decidua; G, giant trophoblast cell layer; S, syncytiotrophoblast layer; L, labyrinthine layer. F & G: Labyrinth layer of placentas of wild type (F) and homozygous mutant (G) embryos. The wild type labyrinthine layer shows normal syncytiotrophoblast differentiation and fetal and maternal vascularization. In the homozygous mutant labyrinth layer, the trophoblast cells appear undifferentiated and are abnormally large and granular. The vascular spaces are reduced compared with the wild type littermate. F, fetal blood vessel; M, maternal blood sinus; T, trophoblast. Placentas were fixed in neutral formalin. Paraffin sections were stained with hematoxylin and eosin. Scale bars: D & E: 50um; F & G: 100um

Copyright

This image is from Zheng B, Proc Natl Acad Sci U S A 2006 Nov 7;103(45):16776-81. Copyright 2006 National Academy of Sciences, U.S.A. J:117102

Associated Alleles

Symbol	Name
Snx13^tm1.1Frq	sorting nexin 13; targeted mutation 1, Marilyn G Farquhar

Associated Genotypes

Allelic Composition	Genetic Background
Snx13^tm1.1Frq/Snx13^tm1.1Frq	involves: 129S1/Sv * 129X1/SvJ * C57BL/6