Phenotype Image Detail

Image

Caption

A: Macroscopic appearance of livers from 1 week old wild type (all at left) and Ahr^tm1Bra/Ahr^tm1Bra (all at right) mice. B & C: Hematoxylin and eosin stained sections of livers from 1 week old wild type and homozygous mutant mice demonstrating extensive microvesicular fatty metamorphosis and extramedullary hematopoiesis in the homozygous mice. D & E: Higher power view of 1 week old wild type and mutant mouse livers. F & G: Hematoxylin and eosin stained liver sections from 2 week old wild type and homozygous mutant mice demonstrating hypercellularity and fibrosis of the portal tract in the homozygous mouse. H & I: Trichrome staining for connective tissue highlighting the portal fibrosis in the homozygous mouse versus the wild type mouse liver.

Copyright

This image is from Schmidt JV, Proc Natl Acad Sci U S A 1996 Jun 25;93(13):6731-6. Copyright 1996 National Academy of Sciences, U.S.A. J:33827

Associated Alleles

Symbol	Name
Ahr^tm1Bra	aryl-hydrocarbon receptor; targeted mutation 1, Christopher A Bradfield

Associated Genotypes

Allelic Composition	Genetic Background
Ahr^tm1Bra/Ahr^tm1Bra	involves: 129S1/Sv * 129X1/SvJ * C57BL/6