Phenotype Image Detail

Image

Caption

Whole mount visualization of wild type (A) and Mapk7^tm1Kda/Mapk7^tm1Kda (B) E9.5 yolk sacs demonstrated that the large collecting vessels present in wild type yolk sacs (arrow) were nearly absent in homozygous mutant mice. Further histological analysis revealed the well defined collecting vessels in wild type sacs (arrow in C) were collapsed and contained fewer blood cells in mutant yolk sacs (arrows in D). Placental vasculature was analyzed in hematoxylin and eosin stained sections of wild type (E) and mutant (F) placentas. Embryonic vessels, as defined by the presence of nucleated red cells, are outlined in red and maternal vessels are outlined in green to better highlight the differences. F: Homozygous mouse placentas had fewer embryonic vessels, and the vessels failed to invade deep into the labyrinth layer as compared to the wild type.

Copyright

This image is from Regan CP, Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9248-53. Copyright 2002 National Academy of Sciences, U.S.A. J:77725

Associated Alleles

Symbol	Name
Mapk7^tm1Kda	mitogen-activated protein kinase 7; targeted mutation 1, Keisuke Kuida

Associated Genotypes

Allelic Composition	Genetic Background
Mapk7^tm1Kda/Mapk7^tm1Kda	involves: 129S6/SvEvTac