Phenotype Image Detail

Image

Caption

Histological appearance of Stk11^tm1.1Jish/Stk11⁺ mice. d-i: Histological examination of polyps at 14 months. (d & f-i) Hematoxylin and eosin staining. (e) Azan staining. (d) Low power section of polyp protruding into gastric lumen. (e) The core of the polyp is formed by a tree-like branching of the muscularis mucosa with connective tissue (arrow). (f) The polyps consist of two types of cells; surface mucous epithelium-like cells (SC) and pyloric gland-like cells (PC) and form glandular tubules like gastric pits (LGP). (g) Surface mucous epithelium like cells of columnar or high columnar type (SC). Pyloric gland like cells have large nuclei and pale cytoplasm (PC). (h) High nuclear density, nuclear atypia, and mitosis (arrowhead) are observed in proportion of proliferating cells. (i) Pyloric gland-like cells also contain eosinophilic material in the cytoplasm. Magnifications: d: x5; e: x20; f: x100; g-i: x200.

Copyright

This image is from Jishage K, Proc Natl Acad Sci U S A 2002 Jun 25;99(13):8903-8. Copyright 2002 National Academy of Sciences, U.S.A. J:77213

Associated Alleles

Symbol	Name
Stk11^tm1.1Jish	serine/threonine kinase 11; targeted mutation 1.1, Kou-ichi Jishage

Associated Genotypes

Allelic Composition	Genetic Background
Stk11^tm1.1Jish/Stk11^+	involves: 129S7/SvEvBrd * C57BL/6J