Phenotype Image Detail

Image

Caption

Histology ( A & B), immunocytochemistry ( C & D) and ultrastructure (E & F) of wild type (A, C & E) and Myh10^tm2Rsad/Myh10^tm2Rsad mouse hearts. A & B: Myocytes from the right ventricular wall of newborn hearts. Note the disarry and larger size of the myocytes in the mutant mouse heart (B). (Hematoxylin and eosin stained). C & D: Fluorescence photomicrographs of heart sections from E18.5 embryos. The green color indicates the presence of NMHC-B in the wild type mouse heart (C) and the lack of green, its absence in the mutant mouse heart (D). Nuclei are stained red with propidium iodide. E & F: Electron micrographs demonstrating myofibrillar disarray in the mutant mouse heart (F) compared with the normal heart (E). Although there is myofibrillar disarray, the myofibrillar components appear normal in the mutant mouse heart. Arrowheads indicate the perinuclear and interfibrillar areas where glycogen particles are present. Scalebars: A & B: 20um; C & D: 10um; E & F: 1um

Copyright

This image is from Tullio AN, Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12407-12. Copyright 1997 National Academy of Sciences, U.S.A. J:44181

Associated Alleles

Symbol	Name
Myh10^tm2Rsad	myosin, heavy polypeptide 10, non-muscle; targeted mutation 1, Robert S Adelstein

Associated Genotypes

Allelic Composition	Genetic Background
Myh10^tm2Rsad/Myh10^tm2Rsad	involves: 129S4/SvJae * C57BL/6J