Phenotype Image Detail

Image

Caption

Ultrastructural changes in hepatocytes of Abcb11^tm1Wng/Abcb11^tm1Wng mice. A: Canalicular changes in hepatocytes in Abcb11^tm1Wng/Abcb11^tm1Wng mice at 6 weeks of age. Bile canaliculus (*) in center of micrograph shows dilated lumen, partial loss of microvilli (arrowhead), and retained biliary material in the form of lamellar and more membranous appearing "fingerprints." B: Cytoplasmic changes in hepatocytes of homozygous mutant mice at 6 weeks of age. Note abundance of peroxisomes (p) and frequent small lipid droplets (L). Peroxisomes are thought to be the site of bile acid metabolism and modification (51). Mitochondria and other organelles are normal as is the hepatic sinusoid(s). C: Hepatocytes of wild type mice at 6 weeks of age. Part of two cells is shown with bile canaliculus (bc). Occasional lipid droplets and an abundance of glycogen (gly) are seen. Part of a normal stellate (Ito) cell is also present. g, Golgi.

Copyright

This image is from Wang R, Proc Natl Acad Sci U S A 2001 Feb 13;98(4):2011-6. Copyright 2001 National Academy of Sciences, U.S.A. J:67548

Associated Alleles

Symbol	Name
Abcb11^tm1Wng	ATP-binding cassette, sub-family B member 11; targeted mutation 1, Renxue Wang

Associated Genotypes

Allelic Composition	Genetic Background
Abcb11^tm1Wng/Abcb11^tm1Wng	involves: 129S6/SvEvTac * C57BL/6J