Phenotype Image Detail

Image

Caption

Collagen (A-C) and elastin (D-F) staining of lung tissue from 7 month old Sftpd^tm1Jhf/Sftpd^tm1Jhf mice. Increased collagen deposition was observed at the pleural surface (A), in focal areas of macrophage accumulation associated with localized fibrosis (B), and in alveolar septa (C) of the homozygous muntant mice. Elastin staining was increased in alveolar septa of homozygous mutant mice (E) compared with age-matched wild type mice (D), the elastic fibers appearing shorter, thicker, and more highly coiled in the homozygous mice. Elastin staining was decreased, however, in alveolar septa (arrows) adjacent to foci of macrophage accumulation and fibrosis (F). Scale bars: A,B,D & E: 50um; C & F: 20um

Copyright

This image is from Wert SE, Proc Natl Acad Sci U S A 2000 May 23;97(11):5972-7. Copyright 2000 National Academy of Sciences, U.S.A. J:62282

Associated Alleles

Symbol	Name
Sftpd^tm1Jhf	surfactant associated protein D; targeted mutation 1, James H Fisher

Associated Genotypes

Allelic Composition	Genetic Background
Sftpd^tm1Jhf/Sftpd^tm1Jhf	involves: 129P2/OlaHsd * Black Swiss