Phenotype Image Detail

Image

Caption

A & B: Histochemical localization of osteoclasts by tartrate-resistant acid phosphatase staining (dark brown) in developing femurs of 10-day-old wild type (A) and Npr3^tm1Unc/Npr3^tm1Unc mice (B). The arrow indicates a secondary ossification center. C & D: Cartilagenous growth plates of femurs from 10-day-old wild type (C) and homozygous mutant (D) mice; hematoxylin and eosin stain. E & F: Picro-Sirus Red staining of bony trabeculae in femurs from 10-day-old wild type (E) and homozygous mutant (F) mice. The amounts of unresorbed mineralized cartilage (MC) and newly deposited bone matrix (arrows) are both increased in the mutant. G & H: In situ hybridization for mouse NPRC mRNA in trabecular bones of 10-day-old wild type (G) and homozygous mutant (H) mice. The signal is specifically localized to the osteoblastic cells lining the bony trabeculae (BT). Magnification: A & B: x40; C & D: x200; E-H: x400

Copyright

This image is from Matsukawa N, Proc Natl Acad Sci U S A 1999 Jun 22;96(13):7403-8. Copyright 1999 National Academy of Sciences, U.S.A. J:56058

Associated Alleles

Symbol	Name
Npr3^tm1Unc	natriuretic peptide receptor 3; targeted mutation 1, University of North Carolina

Associated Genotypes

Allelic Composition	Genetic Background
Npr3^tm1Unc/Npr3^tm1Unc	involves: 129 * C57BL/6