Phenotype Image Detail

Image

Caption

A & B: Proximal (A) and distal (B) views of the dissected SL, PY, and PI bones from a wild-type and a Hoxd11^tm1Ipc/Hoxd11^tm1Ipc forelimb. This mutant shows a grossly misshapen PI bone fused to the PY and a separated PPSL (arrows). C: Proximal view of the same bones from a different pair of specimens. This mutant is not fused to the PY, but is severely truncated. SL and PY are fused, and the PPSL is absent (arrow). D: Palmar views of the distal extremities of the radius (R) and ulna (U) of a wild-type and mutant mouse forelimb. In the mutant, the styloid apophysis of the ulna is flattened and more rounded (open arrow), and an excrescence at the palmar and medial edge of the radius styloid apophysis is less protruding (arrow).

Copyright

This image is from Favier B, Proc Natl Acad Sci U S A 1995 Jan 3;92(1):310-4. Copyright 1995 National Academy of Sciences, U.S.A. J:22289

Associated Alleles

Symbol	Name
Hoxd11^tm1Ipc	homeobox D11; targeted mutation 1, Pierre Chambon

Associated Genotypes

Allelic Composition	Genetic Background
Hoxd11^tm1Ipc/Hoxd11^tm1Ipc	either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)