Phenotype Image Detail

Image

Caption

A-C: Dorsal views of the right forefoot of a wild-type (A) and two Hoxd11^tm1Ipc/Hoxd11^tm1Ipc mutant 1 month old mice ( B & C). These views show the distal extremities of the radius and ulna (SR, styloid process of the radius and SU), two bones of the proximal row [SL and PY (os triquetrium)], the central carpal bone (C), the distal row of the carpus (only two bones are labeled, D2 distal carpal 2; D4, distal carpals 4 and 5 fused into the os hamatum), and the metacarpal bones (II to V). The defects seen in both mutant forelimbs include the shortening of metacarpal bones II,III, and IV (note also the malformation of the head of metacarpal II in B, black arrow) and the flattening of the SU, which is more severe in C. The forelimb in B displays a fusion between the SL and the PY (arrowheads) whereas C shows the only adult mutant with separated lunate and scaphoid bones. D-F: Palmar views of the right carpus of a wild-type (D) and of the right (E) and left (F) carpus of the same mutant mouse, which are thus mirror images. These views show the PI, adjacent to and partly hiding the PY, as well as the PPSL, which has been outlined in white. Both mutant limbs show a full separation of the PPSL, a truncated medial process of the SR (arrowheads), and a malformed head of the PI. A large supernumerary bone is found medially from the SU (arrow in F).

Copyright

This image is from Favier B, Proc Natl Acad Sci U S A 1995 Jan 3;92(1):310-4. Copyright 1995 National Academy of Sciences, U.S.A. J:22289

Associated Alleles

Symbol	Name
Hoxd11^tm1Ipc	homeobox D11; targeted mutation 1, Pierre Chambon

Associated Genotypes

Allelic Composition	Genetic Background
Hoxd11^tm1Ipc/Hoxd11^tm1Ipc	either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)