Phenotype Image Detail

Image

Caption

A: Immunohistochemical staining for K14 (dark gray) in a sagittal section from a normal neonatal incisor localizes to the reduced enamel epithelium (re) on the labial surface. B: Eruption of both incisors and molars (enlarged in Insets) is readily apparent in the maxilla and mandible of an adult Pthlh^tm1Hmk/Pthlh^tm1Hmk mouse expressing Tg(Col2a1-PTHLH)2Ecw and Tg(KRT14-PTHLH)7Wmp. C: A sagittal radiograph of an adult homozygous mouse expressing Tg(Col2a1-PTHLH)2Ecw and Tg(KRT14-PTHLH)7Wmp clearly reveals the malocclusion of the incisors caused by the underlying chondrodystrophy. Note the restoration of root extension in the lower incisor (arrowhead). Scalebar: 27um

Copyright

This image is from Philbrick WM, Proc Natl Acad Sci U S A 1998 Sep 29;95(20):11846-51. Copyright 1998 National Academy of Sciences, U.S.A. J:50144

Associated Alleles

Symbol	Name
Pthlh^tm1Hmk	parathyroid hormone-like peptide; targeted mutation 1, Henry M Kronenberg
Tg(Col2a1-PTHLH)2Ecw	transgene insertion 2, Eleanor C Weir
Tg(KRT14-PTHLH)7Wmp	transgene insertion 7, William M Philbrick

Associated Genotypes

Allelic Composition	Genetic Background
Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-PTHLH)2Ecw/0 Tg(KRT14-PTHLH)7Wmp/0	involves: 129S2/SvPas * C57BL/6 * SJL