Phenotype Image Detail

Image

Caption

A-F: Histological sections of undecalcified tibiae stained with hematoxylin and eosin from wild-type mice (A, B), hemizygous (C,D) and homozygous (E,F) Tg(Col2a1-PTHR1*H223R)AHju littermates at day 17.5 of fetal development. Panels B,D and F are higher magnifications of the boxed area in A, C and E, respectively. G & H: Histological sections of undecalcified tibiae from a newborn wild-type mouse (G) and a Tg(Col2a1-PTHR1*H223R)BHju/Tg(Col2a1-PTHR1*H223R)BHju (H) littermate stained with hematoxylin and eosin. I & J: Histological sections of undecalcified tibiae from a 17.5 day Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju fetus (I) and a Tg(Col2a1-PTHR1*H223R)BHju/Tg(Col2a1-PTHR1*H223R)BHju newborn mouse (J) stained by the method of von Kossa.

Copyright

This image is from Schipani E, Proc Natl Acad Sci U S A 1997 Dec 9;94(25):13689-94. Copyright 1997 National Academy of Sciences, U.S.A. J:77639

Associated Alleles

Symbol	Name
Tg(Col2a1-PTHR1*H223R)AHju	transgene insertion A, Harald Juppner
Tg(Col2a1-PTHR1*H223R)BHju	transgene insertion B, Harald Juppner

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju	involves: C57BL/6
Tg(Col2a1-PTHR1*H223R)AHju/0	involves: C57BL/6
Tg(Col2a1-PTHR1*H223R)BHju/Tg(Col2a1-PTHR1*H223R)BHju	involves: FVB/N