Phenotype Image Detail

Image

Caption

A: An E16 Lrp6^Cd/Lrp6^Cd exencephalic embryo has normal limbs and no tail truncation. B: The same E16 embryo after skeletal staining with alizarin red (bone) and alcian blue (cartilage) (right forepaw shown in Inset). Tail vertebrae are unstained because cutaneous tissue was not dissected away. C: Forepaw from another E16 homozygous embryo and a wild-type sibling. D: E14 homozygous mutant exencephalic embryo has a crooked tail with irregular somites including a hemivertebra (arrow on left), a deformed somite (right arrow with asterisk), two small somites (double arrowhead), and deformed somite creating a second bend in the tail (single arrowhead). Asterisks indicate the equivalent somite in the wild-type and homozygous siblings. E: Skeletal defects in an adult homozygous mutant male mouse that closed the neural tube. Scattered caudal coccygeal and lumbar vertebrae are malformed. Abbreviations: coccygeal (C); lumbar (L)

Copyright

This image is from Carter M, Proc Natl Acad Sci U S A 2005 Sep 6;102(36):12843-8. Copyright 2005 National Academy of Sciences, U.S.A. J:101423

Associated Alleles

Symbol	Name
Lrp6^Cd	low density lipoprotein receptor-related protein 6; crooked