Phenotype Image Detail

Image

Caption

B & C: Skeletal staining, side view comparison, of the head of a Lhx8^tm1Lmgd/Lhx8^tm1Lmgd (C) with a wild-type control (B) shows that the craniofacial features of the homozygous mutant mouse with cleft palate appears grossly normal. Arrows and arrowheads point at the tip and the middle part of the mandibles in both mice. D & E: Top view of the mandible of the Lhx8^tm1Lmgd/Lhx8^tm1Lmgd (E) with cleft palate compared to the wild-type control (D). The mandible of the homozygous mutant appears normal. F & G: Ventral view comparison of the upper jaw of the Lhx8^tm1Lmgd/Lhx8^tm1Lmgd (G) mouse and wild-type control (F) indicates a cleft of the secondary palate (arrowheads) in the homomzygous mutant mouse. H & I: Ventral view comparison of the base of skulls of newborn Lhx8^tm1Lmgd/Lhx8^tm1Lmgd (I) and wild-type mice (H) stained with alcian blue and alizarin red. The palatal bones in the homozygous mutant failed to grow toward the midline (arrowheads). Scalebar: A: 6.6mm; B-I: 1.3mm

Copyright

This image is from Zhao Y, Proc Natl Acad Sci U S A 1999 Dec 21;96(26):15002-6. Copyright 1999 National Academy of Sciences, U.S.A. J:59082

Associated Alleles

Symbol	Name
Lhx8^tm1Lmgd	LIM homeobox protein 8; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated Genotypes

Allelic Composition	Genetic Background
Lhx8^tm1Lmgd/Lhx8^tm1Lmgd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Lhx6^tm1And/Lhx6^tm1And Lhx8^tm1Lmgd/Lhx8^tm1Lmgd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1