Phenotype Image Detail

Image

Caption

H&E staining of coronal section through the palatal region of the Lhx8^tm1Lmgd/Lhx8^tm1Lmgd embryos at E13.5 (B), E14.5 (D) and E16.5 (F) as compared with age matched wild-type embryos (A,C, & E). Arrowheads point at the palatal shelves that were not in contact ( A,B,D & F), were in contact (C) or were completely fused (E). Arrows point at one of the upper molar tooth buds in all panels. G & H: H&E stained coronal sections through the distal region of the mandible of a wild-type (G) and Lhx8^tm1Lmgd/Lhx8^tm1Lmgd embryo at E16.5 with a cleft palate, showing normal development of the mandible, incisor teeth and the Meckel's cartalage in the homozygous mutant. Abbreviations: Meckel's cartilage (m) Scalebar: A-F: 200um; G-H: 80um

Copyright

This image is from Zhao Y, Proc Natl Acad Sci U S A 1999 Dec 21;96(26):15002-6. Copyright 1999 National Academy of Sciences, U.S.A. J:59082

Associated Alleles

Symbol	Name
Lhx8^tm1Lmgd	LIM homeobox protein 8; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated Genotypes

Allelic Composition	Genetic Background
Lhx8^tm1Lmgd/Lhx8^tm1Lmgd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6