Phenotype Image Detail

Image

Caption

In the Sox9^tm1CrmSox9⁺ (B & D) all precartilaginous skeletal elements using Alcian blue staining exhibit a reduced staining intensity and are smaller then the +/+ controls (A & C). The cartilage primordia of scapula consists of two small pieces instead of a single intact element. Hematoxylin/eosin staining of transverse sections through thoracic regions (E & F) indicate cells in the sclerotome surrounding the notchcord (arrowhead) appears like mesenchymal cells in the Sox9^tm1Crm/Sox9⁺ (F) but are typical cobblestone-like prechondrocytic cells in the +/+ control (E). Abbreviations: scapula (S); humerus (H); radius (R); ulna (U); femur (F); fibula (Fi); tibia (T) prevertebrae (PV).

Copyright

This image is from Bi W, Proc Natl Acad Sci U S A 2001 Jun 5;98(12):6698-703. Copyright 2001 National Academy of Sciences, U.S.A. J:69875

Associated Alleles

Symbol	Name
Sox9^tm1Crm	SRY (sex determining region Y)-box 9; targeted mutation 1, Benoit de Crombrugghe

Associated Genotypes

Allelic Composition	Genetic Background
Sox9^tm1Crm/Sox9^+	involves: 129S7/SvEvBrd * C57BL/6 * CD-1