Phenotype Image Detail

Image

Caption

Panels A & B: Expression of the kinesin protein KIF17b in the mature sperm in the principal piece of the sperm tail in both +/+ (left) and Fhl5^tm1Saco/Fhl5^tm1Saco (right) mice. The nuclei are indicated by arrowheads, the position of the unstained midpeice of the sperm tail is indicated by the arrow, which shows the orientation of the tail, pointing toward its tip. Magnification X300. Panels C & D: Phase-contrast microscopy shows a much greater amount of tail folds in the sperm of Fhl5^tm1Saco/Fhl5^tm1Saco mice. Maginifaction X150. Panel E: Percentages of tail folds in comparison with the number of total counted cells. Panel F: Representations of abnormally shaped heads of sperm from Fhl5^tm1Saco/Fhl5^tm1Saco in comparison with the +/+ wild-type (upper left). Magnification X300

Copyright

This image is from Kotaja N, Proc Natl Acad Sci U S A 2004 Jul 20;101(29):10620-5. Copyright 2004 National Academy of Sciences, U.S.A. J:91483

Associated Alleles

Symbol	Name
Fhl5^tm1Saco	four and a half LIM domains 5; targeted mutation 1, Paolo Sassone-Corsi

Associated Genotypes

Allelic Composition	Genetic Background
Fhl5^tm1Saco/Fhl5^tm1Saco	involves: 129S2/SvPas * C57BL/6