Phenotype Image Detail

Image

Caption

Calvaria harvested from E18.5 embryos of wildtype (a-h) and Fgfr2^tm1Schl/Fgfr2⁺ mice (i-p) were cultured either with vehicle alone or with PLX052, an inhibitor of FGFR, for 2 weeks. Histological sections of cultured calvaria were made perpendicular to the coronal suture, which passes through the frontal bone and the parietal bone. Sections stained with tiluidine blue (a,c,e,g,i,k and o). and adjacent sections were stained by von Kossa followed by methyl green counter staining (b, d,f,h,j,l,n, and p). Lower [c,d,g,h,k,l,o and p (Scale bars 100um)] show the higher magnification of the coronal sutures shown in the boxed regions of Upper [a,b,e,f,i,j,m, and n (Scale bars 500um)] respectively. Open (arrow) and fused coronal sutures (arrowheads) are indicated. Fused sutures are observed in untreated calcaria from Fgfr2^tm1Schl/Fgfr2⁺ mice (i-l). amd open sutures are observed in calvaria from Fgfr2^tm1Schl/Fgfr2⁺ mice treated with PLX052 (m-p).

Copyright

This image is from Eswarakumar VP, Proc Natl Acad Sci U S A 2006 Dec 5;103(49):18603-8. Copyright 2006 National Academy of Sciences, U.S.A. J:118299

Associated Alleles

Symbol	Name
Fgfr2^tm1Schl	fibroblast growth factor receptor 2; targeted mutation 1, Joseph Schlessinger

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm1Schl/Fgfr2^+	involves: 129S1/Sv